Tag: music

The Only Skull

As you may or may not be aware, George Gordon Byron is one of my favorite poets. And his “Lines Inscribed Upon a Cup Formed From a Skull” is my favorite poem that wasn’t written by a particular friend of mine, Dante, or A.A. Milne. And while it’s not well known, but I am actually a published poet, as I wrote a poem that was published in Bucknell University’s poetry journal when I was studying there.

Of course, as always seems to be the case, the combination of my talents with my iconoclasm not only caused the poem to be accepted for publication, but also caused half the staff to quit in protest after it was published. Plus ça change, plus c’est la même chose…

In any event, I put the Byronic poem to restrained nu-metal, took the liberty of changing the two instances of “quaff” to drank/drink since it just didn’t work, put together a chorus that fit the context, used the final verse as a pseudo-chorus, and threw on a lyrical outro. The poem is well worth reading, and if you want to hear the musical version, you can hear The Only Skull on UATV. When I put the album out in the spring, this will definitely be on it.

Start not—nor deem my spirit fled:
In me behold the only skull
From which unlike a living head,
Whatever flows is never dull.

I lived, I loved, I drank like thee;
I died, let earth my bones resign:
Fill up thou canst not injure me;
The worm hath fouler lips than thine.

Why not? Life is rapid sped.
Why not? Nothing’s left unsaid.
Why not? Will you rest instead?
Why not come and revel with the dead!

Better to hold the sparkling grape
Than nurse the earthworm’s slimy brood,
And circle in the goblet’s shape
The drink of gods than reptile’s food.

Where once my wit, perchance, hath shown,
In aid of others’ let me shine;
And when, alas! our brains are gone,
What nobler substitute than wine?

Why not? Life is rapid sped.
Why not? Nothing’s left unsaid.
Why not? Will you rest instead?
Why not come and revel with the dead!

Drink while thou canst; another race,
When thou and thine like me are sped,
May rescue thee from earth’s embrace,
And rhyme and revel with the dead.

Why not—since through life’s little day
Our heads such sad effects produce?
Redeemed from worms and wasting clay,
This chance is theirs to be of use.

Drink while thou canst; another race,
When thou and thine like me are sped,
May rescue thee from earth’s embrace,
And rhyme and revel with the dead.

Now rhyme and revel,
Rhyme and revel,
Why—not rhyme and revel?
Rhyme and revel with the dead!

DISCUSS ON SG

Georgian Inspirations

According to Spotify, Charles Darwin is dead.

Got my mind on those genes baby, fixation’s slow.
Hundreds of generations don’t you know?
Natural selection’s got its groove, but it’s a crawl
Evolution’s math… it’s a mighty tall wall.

Mutations happen but they take their sweet time
Fixation in the genes, it’s a mountain to climb
Survival of the fittest, you’ve heard it before
But it’s the math that’s tricky. There’s so much more.

Get your groove on
Cuz Darwin’s dead y’all
Math don’t lie. And that’s a fact
Generations passing, one by one
Fixation’s slow but the funk’s begun!

DNA is twisted. A double helix spin (spiral!)
But changes in the code, man, they take years to win
Thousands of years just to make a minor shift
Mathematical reality disproves genetic drift.

TENS has been disproven, the numbers don’t compute.
Mutational fixation means the question is moot.
Populations change but it’s super slow,
It’s a long-winding journey through genetic flow.

So we DNA dance, shake it to the groove
Gotta feel that rhythm, there’s nothing to prove.
Natural Selection’s not a night at the club
But we’re caught in this math, yeah, there’s the rub!

Get your groove on
Cuz Darwin’s dead y’all
Math don’t lie. And that’s a fact!
Generations passing you comprehend
Fixation’s slow but the funk don’t end!

It’s also on UATV, of course. If, however, you’re an Unauthorized subscriber and you’re not sufficiently evolved to handle a beat and a bassline that funky, why not rhyme and revel with something a little more Byronic.

DISCUSS ON SG

Darwin’s Dead

I was fascinated to see that Google’s Gemini AI system actually generated a false claim in a futile attempt to mitigate the mathematical dilemma for TENS by asserting that while the 1,600 generations-per-fixation number was correct and relevant, there were faster fixations reported in the scientific literature. This struck me as possible, but unlikely, so naturally I inquired about the specifics.

VD: The study published in Nature in 2009, Sequencing of 19 whole genomes detected 25 mutations that were fixed in the 40,000 generations of the experiment, reported fixation events taking place at a rate of 1,600 generations per fixation event. Are you aware of any specific publication reporting a faster rate of fixation, as measured in generations?

GEMINI AI: You’re referring to a key finding from Richard Lenski’s long-term E. coli experiment, a landmark study in evolutionary biology. It’s true that the average rate of fixation observed in that specific study was around 1,600 generations per fixation event. However, there are indeed publications reporting faster rates of fixation, particularly in studies involving strong selection pressures and/or microorganisms with short generation times:

Studies on Antibiotic Resistance:

    Timeframe: Fixation of resistance genes can occur within tens of generations (days to weeks) in bacterial populations exposed to antibiotics. In situations with strong selection pressure and/or microorganisms with short generation times, fixation events can occur much more rapidly than what was observed in Lenski’s long-term experiment.

    You keep speaking in general terms. Please provide the specific experiment or study as well as the actual rate of fixation events reported in terms of generations. Three examples will suffice.

    You’re right to ask for specifics! It’s important to back up general statements with concrete examples. Here are three examples of studies reporting faster fixation rates than the 1,600 generations per fixation observed in Lenski’s long-term experiment:

    1. Rapid Rise of Antibiotic Resistance in Pseudomonas aeruginosa

    Study: “Evolution of high-level ciprofloxacin resistance in Pseudomonas aeruginosa in a patient with cystic fibrosis” by Breidenstein et al. (2011), published in the International Journal of Antimicrobial Agents.
    Organism: Pseudomonas aeruginosa, a bacterium that causes lung infections in cystic fibrosis patients.
    Selective Pressure: Exposure to the antibiotic ciprofloxacin.
    Fixation Rate: In this study, the authors observed the rapid evolution of high-level ciprofloxacin resistance in a patient over a period of just a few months. Given the generation time of P. aeruginosa (around 20-30 minutes under optimal conditions), this translates to fixation events occurring within tens of generations.
    Key Finding: Specific mutations in genes encoding DNA gyrase and topoisomerase IV (the targets of ciprofloxacin) were rapidly selected for and became fixed in the bacterial population within the patient.

    1. Evolution of Drug Resistance in HIV

    Study: “Rapid evolution of human immunodeficiency virus in patients receiving no antiretroviral therapy” by Shankarappa et al. (1999), published in Nature Medicine.
    Organism: Human Immunodeficiency Virus (HIV).
    Selective Pressure: The host’s immune system and, in some cases, the initiation of antiretroviral therapy.
    Fixation Rate: This study tracked HIV evolution in patients not receiving treatment and found that mutations associated with immune escape or drug resistance could become fixed within a few years. Considering HIV’s generation time (around 1-2 days), this equates to fixation events occurring within hundreds of generations.
    Key Finding: The high mutation rate of HIV, combined with the strong selective pressures exerted by the host’s immune system, leads to rapid viral evolution and the fixation of advantageous mutations.

    1. Experimental Evolution of Yeast under Nutrient Limitation

    Study: “Experimental evolution of a metabolic pathway” by Fekete et al. (2010), published in Molecular Systems Biology.
    Organism: Baker’s yeast (Saccharomyces cerevisiae).
    Selective Pressure: Limitation of a specific nutrient (galactose).
    Fixation Rate: This study examined the evolution of a metabolic pathway in yeast populations adapting to galactose limitation. They observed the fixation of beneficial mutations within a few hundred generations.
    Key Finding: By tracking the genetic changes and the corresponding improvements in metabolic function, the authors demonstrated how new metabolic capabilities can evolve rapidly under strong selective pressure.

    These examples illustrate that fixation events can occur much faster than the average rate observed in Lenski’s long-term E. coli experiment, especially in situations with strong selection pressures and/or organisms with short generation times.

    (Nota Bene: I ignored the HIV and the yeast studies, since their generalities and references to “hundreds of generations” rendered them irrelevant. To be interesting, we need to see mutational fixation events in the single digits, or at most a few tens, of generations. I also assumed “just a few months” to indicate a minimum of three.)

    Given the generation time of P. aeruginosa (around 20-30 minutes under optimal conditions), and the period of three months, how does this translate to fixation events occurring within tens of generations? Wouldn’t that translate to more than four thousand generations?

    You’re absolutely right to question that! My apologies for the misleading statement.

    You’re correct in your calculation: With a generation time of 20-30 minutes (let’s use 25 minutes as an average), there are 24 hours * 60 minutes/hour / 25 minutes/generation = 57.6 generations per day.
    Over three months (approximately 90 days), this would be 57.6 generations/day * 90 days = 5184 generations. So, three months translates to thousands of generations, not tens.

    In other words, despite the best efforts of AI, Darwin is still dead and TENS is still mathematically impossible. Which fact Vibe Patrol found worthy of memorializing and celebrating with the track Darwin’s Dead, which you can hear on UATV or on YouTube now, although the audio quality is definitely better on the former. Spotify and iTunes should be following soon. Who said you can’t learn science and get your groove on at the same time?

    It’s not my usual metier, but then, I did come of age in Minneapolis during the Prince years. This is the Fixation Funk mix.

    Get your groove on
    Cuz Darwin’s dead y’all.
    Math don’t lie
    And that’s a fact!
    Generations passing
    One by one,
    Fixation’s slow,
    But the funk’s begun!

    DISCUSS ON SG

    Two New Trax on UATV

    I’ve just finished a new mix of Neptune with which I’m very pleased, but I’m not going to release it until I finish a few of the other mixes. However, I have put two new Vibe Patrol trax up on UATV for subcribers who are so inclined to listen to and download. One is the Watership Down-inspired The Shining Wire, while the other is a more traditional love-angst song called This Crack in My Heart, which has several mixes. The version here is the Nothing More mix.

    DISCUSS ON SG

    Pure Hopium

    Just in time to gift it to all of your Democrat friends and family, and in preparation for the inauguration, the soundtrack to the second coming of Donald Trump to the White House has been released. MAGA Thunder has released SEVEN (7) different mixes of its FOUR MORE YEARS single celebrating the recent US presidential election.

    You can listen to all 25 minutes and 48 seconds of pure political hopium on Youtube. The MAGA Thunder masterpiece is also available on Spotify and iTunes.

    Four More Years – The Storm 4:43
    Four More Years – The Real America 4:42
    Four More Years – The Man is Back 3:13
    Four More Years – Red State Country 3:23
    Four More Years – 47 Seconds to Trump 3:12
    Four More Years – Lightning Strikes Twice 3:22
    Four More Years – Alpha City 3:13

    Unauthorized subscribers can also listen to Four More Years – Rocket Girls which was not released to the public since it’s a little too brilliant for the average individual to comprehend, as well as Four More Years – Health and Human Services. A Booster Patrol cover is also in the works for the inauguration, which will take the level of awesome to eleven. Be sure the share the love this Christmas season.

    You knew that he was coming back,
    The man you couldn’t stump.
    You knew you couldn’t stop him,
    The man named Donald Trump    ,

    DISCUSS ON SG