Overvaccination and brain inflammation

It appears that researchers may be zooming in on the nexus that connects vaccines and vaccine-related developmental issues:

Analyzing five years’ worth of private health insurance data on children ages 6-15, these scientists found that young people vaccinated in the previous three to 12 months were significantly more likely to be diagnosed with certain neuropsychiatric disorders than their non-vaccinated counterparts.

This new study, which raises important questions about whether over-vaccination may be triggering immune and neurological damage in a subset of vulnerable children (something parents of children with autism have been saying for years), was published in the peer-reviewed journal Frontiers in Psychiatry, Jan. 19.

More than 95,000 children in the database that were analyzed had one of seven neuropsychiatric disorders: anorexia nervosa, anxiety disorder, attention deficit and hyperactivity disorder (ADHD), bipolar disorder, major depression, obsessive-compulsive disorder (OCD) and tic disorder.

Children with these disorders were compared to children without neuropsychiatric disorders, as well as to children with two other conditions that could not possibly be related to vaccination: open wounds and broken bones.

This was a well-designed, tightly controlled study. Control subjects without brain disorders were matched with the subjects by age, geographic location and gender.

As expected, broken bones and open wounds showed no significant association with vaccinations.

New cases of major depression, bipolar disorder or ADHD also showed no significant association with vaccinations.

However, children who had been vaccinated were 80 percent more likely to be diagnosed with anorexia and 25 percent more likely to be diagnosed with OCD than their non-vaccinated counterparts. Vaccinated children were also more likely to be diagnosed with an anxiety disorder and with tics compared to the controls.

Now, I’m as dubious as anyone about the legitimacy of psychiatric disorders, so I wouldn’t put too much stock in the main thrust of the story. But here is the potentially more significant issue that is not readily apparent. The tests which revealed the brain inflammation by which the psychiatric disorders are believed to have been caused occurred in children who were receiving shots as young as five. This raises the obvious question: what is happening to the brains of smaller, younger children who are receiving even more shots than their older counterparts?

Before the usual suspects on both sides of the vaccine debate react instinctively, keep in mind that this isn’t a question of the known benefits of vaccines or the known risks. This is a matter of balancing the known knowns against the known unknowns, which, by definition, cannot possibly be done until more can be learned about the unknowns. And even if any one vaccine, or series of vaccines, are beneficial, that does not mean that overvaccination is impossible, particularly if each shot causes a small amount of brain inflammation.

One shot of tequila won’t hurt you either. That doesn’t mean 25 in quick succession are harmless.


Vaccine lawsuit in Japan

This anti-Gardisil lawsuit could prove interesting, as Big Pharma’s political influence is considerably less in Japan:

Sixty-three young women are seeking a combined 945 million yen ($9 million) in compensation in the first mass lawsuit concerning side effects from cervical cancer vaccines.

The women are suing the central government and pharmaceutical companies GlaxoSmithKline Plc and MSD KK.

The lawsuits were filed July 27 in the district courts at Tokyo, Osaka, Nagoya and Fukuoka. The plaintiffs are aged between 15 and 22.

The women argue they have suffered health problems, such as pain in various parts of their bodies, difficulty in walking and also impaired eyesight, as a result of taking the vaccines that were meant to prevent cervical cancer.

They were mostly in junior or senior high school when they took the vaccines between July 2010 and July 2013.

The vaccines under question are GSK’s Cervarix, which was approved for domestic use in 2009, and MSD’s Gardasil, which was approved in 2011.

The plaintiffs argue that reports had been filed overseas where the two vaccines were in use before Japan about various side effects, including cases of death and serious illness.

On the downside, it looks as if the Japanese government is one of the defendants, which may be a tactical blunder by the plantiffs’ lawyers. But perhaps not; I know very little about the Japanese legal system. However, Japan is very big on taking full responsibility even when the individual is known not to be directly to blame, so I expect the pharmaceutical companies’ customary utilitarian defenses will not go over particularly well.


Vaccine safety and “ovarian failure”

Once more, we see that those oh-so-trustworthy scientists appear to have carefully buried the risks in the name of not allowing parents to make informed decisions about what they inject into their children:

The HPV vaccine is heavily pushed to both teen girls and boys. Even though countries such as Japan won’t formally have stated that they don’t want to support it, the United States continues to massively push this vaccine despite all the push back world-wide. The HPV money grab by pharmaceutical companies is blatant and unchecked. Well, now things just got a whole lot worse: The American College Of Pediatricians has announced that the HPV vaccine is “possibly” associated with ovarian cancer. You can view the document here.

     It has recently come to the attention of the College that one of the recommended vaccines could possibly be associated with the very rare but serious condition of premature ovarian failure (POF), also known as premature menopause.

The rest of the press release is a defensive mess, claiming that the studies aren’t proof positive. But here’s the thing, if the ACP is admitting this small amount, imagine how large the actual issue likely is? They are always in a mode of protection when it comes to this vaccine, it creates a lot of revenue, so for them to admit this is a really big deal.

Pharmaceutical companies do not want any negative publications regarding Gardasil. And certainly, they’ve coerced and influenced this organization into not putting out negative claims over the matter. This tells me that this new discovery is huge and creates potential liability for them. It is so big that they actually fear not disclosing it.

It’s amazing that so many scientists insist on continuing to do the one thing that is ABSOLUTELY GUARANTEED to destroy all trust in them, which is point-and-shriek at those who do nothing more than dare to notice all the little anomalies and ask questions about the doubts that are quite naturally raised by their behavior.

Go ahead, shriek some more about Jenny McCarthy killing people. That’s ever-so-convincing to everyone who wonders about your integrity.


Science SJWs always lie

Orac Knows is always looking for a chance to take a shot at me because I spank him every time he tries to attack  my vaccine skepticism or whatever. He’s a typical scientist, educated, but not very smart, and totally unable to grasp the fact that his science degree doesn’t make him a match for an opponent with a significant advantage in intelligence.

He tried to leap on the fact that, according to him, the study cited by the New York Times in the story I linked to yesterday was flawed, and thereby claim that I don’t know what I am talking about.

There was just one little problem with that. I never read the study. I never pretended to read the study. I neither linked to nor cited the study.

From @oracknows: Quoth Vox Day: Antivaxers are more educated. Quoth the study Vox cites: Not exactly…

Vox Day @voxday 
You’re dishonest, Orac. More educated does not mean more intelligent. Look at us. You have more education. I’m smarter.

Orac ‏@oracknows
Of course, it amuses me that someone who is so “smart” didn’t seem to understand what the study he touts actually says. 🙂

Vox Day @voxday
You prove my point. I never read any study. I merely linked to the New York Times. You’re not amused, you’re dishonest.

Orac ‏@oracknows
In other words, to borrow a phrase from @WilliamShatner, I’m laughing at the superior intellect.

Vox Day @voxday 
My intellect is observably superior to yours. And you’re not laughing. You’re posturing.

Orac ‏@oracknows
Nope. I’m mocking you for being so lazy and anxious to believe the NYT version that you didn’t bother to check!

Vox Day @voxday
Why would I check it? I don’t check most news sources I link. The only
person leaping at anything is you. Why attack me, not NYT?

Vox Day ‏@voxday
And you also claimed I cited the study. I didn’t. You even knew I didn’t. You lied. See, YOU, I would check. Because you lie.

Vox Day ‏@voxday
Proof @oracknows lied:

1. “Quoth the study Vox cites”
2. “it’s obvious that he just read the news…but didn’t actually look up the paper”

Notice how as soon as he’s busted on his two bait-and-switches – he tries to substitute “more intelligent” for “more educated” and “Vox is stupid because he got it wrong” for “I think the New York Times got it wrong”, he tries to back up and say that he’s just mocking me for excessive credulity in citing the New York Times.

You know, the leading American liberal news standard. Someone had better alert Wikipedia! The New York Times is no longer a reliable source!

This is like me claiming someone doesn’t understand economics because they cited GDP or inflation figures reported in the Wall Street Journal. It’s just ludicrously dishonest. But then, Orac isn’t actually interested in correcting the science or he would have focused on the New York Times and not me. He’s just another SJW with such short-term time preferences that he’s willing to throw his own reputation as well as the reputation of a liberal newspaper and a science reporter under the bus just to take an ill-advised shot at me.

The funny thing is that Spacebunny can land a killshot 100x more effective than all the SJWs desperately flailing about, and she can do it with considerably less effort.

UberFacts @UberFacts
A study found that astronauts had more difficulty doing things that required spacial reasoning and motor skills after 6 months in space.

Space Bunny ‏@Spacebunnyday
@voxday would come back a vegetable…..


Anti-vaxxers are MORE educated

The news that anti-vaxxers are whiter, wealthier, and better-educated than those who place blind faith in vaccines won’t surprise anyone who has actually engaged a vaccine enthusiast on the subject. None of them know anything about history, few of them know anything about science, and all of them are prone to simply repeating the usual vaccine scare rhetoric:

The people most likely to refuse to have their children vaccinated tend to be white, well-educated and affluent, researchers report.

A study published in the January issue of the American Journal of Public Health used California state government data on “personal belief exemptions,” or opting out of vaccinations for nonmedical reasons. From 2007 to 2013, the rate of vaccine refusal for personal belief doubled, to 3.06 percent.

The researchers reviewed data among all kindergarten children in the state during that time. More than 17,000 children, attending 6,911 schools, were exempted.

Exemption percentages were generally higher in regions with higher income, higher levels of education, and predominantly white populations. In private schools, 5.43 percent of children were exempt, compared with 2.88 percent in public schools.

In some suburban areas, rates of exemption were near 50 percent, and more than a quarter of California’s schools have measles immunization rates below the 92 to 94 percent required for herd immunity, the level of vaccination necessary to protect people who are not immune.

The very simple fact of the matter is that vaccines are far, far less important in halting the spread of infectious disease than controlling entry and immigration from non-first world countries. This is obvious, since vaccine rates are still very high in the USA and Western Europe, and yet there is a massive rise in various diseases that is the direct result of global travel and large-scale immigration.

The idea that the current vaccine schedule is responsible for the huge decline in deaths from infectious diseases in the 19th century is not merely ahistorical, it requires a combination of ignorance and stupidity. This will become readily apparent before long as most children will continue to be vaccinated but disease rates will continue to rise thanks to the behavior and lifestyles of the New Americans.

You can be reliably certain that a position is wrong if it is inordinately held by magical thinkers or cargo cult scientists. Vaccines aren’t magic, they are merely a medical tool that is useful in some circumstances and useless in others. The simple and science-based fact is that most children don’t need most vaccines.


Scientistry is not scientody

Nature reports how more rigorous documentation requirements are demonstrating the intrinsic unreliability of scientistry (the profession of science) and showing how the substitution of scientistry for scientody (the actual scientific process) makes what subsequently passes for science unreliable.

The launch of the clinicaltrials.gov registry in 2000 seems to have had a striking impact on reported trial results, according to a PLoS ONE study1 that many researchers have been talking about online in the past week.

A 1997 US law mandated the registry’s creation, requiring researchers from 2000 to record their trial methods and outcome measures before collecting data. The study found that in a sample of 55 large trials testing heart-disease treatments, 57% of those published before 2000 reported positive effects from the treatments. But that figure plunged to just 8% in studies that were conducted after 2000. Study author Veronica Irvin, a health scientist at Oregon State University in Corvallis, says this suggests that registering clinical studies is leading to more rigorous research. Writing on his NeuroLogica Blog, neurologist Steven Novella of Yale University in New Haven, Connecticut, called the study “encouraging” but also “a bit frightening” because it casts doubt on previous positive results.

Irvin and her co-author Robert Kaplan, chief science officer at the Agency for Healthcare Research and Quality in Rockville, Maryland, focused on human randomized controlled trials that were funded by the US National Heart, Lung, and Blood Institute (NHLBI). The authors conclude that registration of trials seemed to be the dominant driver of the drastic change in study results. They found no evidence that the trend could be explained by shifting levels of industry sponsorship or by changes in trial methodologies.

Translation: there is good reason to be dubious about more than 7 in every 8 historical corporate sponsored medical trials. Keep this in mind when you are basing an argument in support of the safety and efficacy of vaccines on research published by the pharmaceutical industry.

This higher standard of documentation is very welcome, but it underlines the way in which that the human factor is the weak link in the scientific process. No amount of “training” can substitute for forcing scientists to be completely transparent about their work.


No, Virginia, vaccines are not safe

As I keep pointing out to little avail, to claim that vaccines are either intrinsically safe or intrinsically unsafe is to miss the point entirely:

Mexico’s public health system has suspended infant vaccines after two babies died and 29 were sickened in an impoverished community.

Six of the 29 babies are in grave condition after receiving vaccinations for tuberculosis, rotovirus and Hepatitis B, which are generally administered between 0 and 6 months, according to a national schedule. The cause of the adverse reactions is not known, the Mexican Institute for Social Security said Sunday.

The institute said it stopped vaccines nationwide on Saturday as a precaution.

To even attempt to discuss “vaccine safety” as a single, uniform subject is blitheringly stupid. I am neither an “anti-vaxxer” nor a “pro-vaxxer”, I simply believe that each vaccine, each combination of vaccines, and each vaccine schedule need to be considered separately, and to take the age, size, and risk profile of the recipient into account. People seem to understand that holistic “car safety” is a not a meaningful subject when contemplating the difference between the crash tests of an old Pinto and a modern Humvee, so it’s bizarre that they insist on lumping a single tetanus vaccine for a 200-pound adult in with a series of shots given to a 12-pound infant under the single topic of “vaccine safety”.


The limits of vaccines

Tetyana Obukhanych, PhD, writes an open letter to the California legislature that is foolishly, and unconstitutionally, considering putting an end to all legal vaccine exemptions:

Dear Legislator:

My name is Tetyana Obukhanych. I hold a PhD in Immunology. I am writing this letter in the hope that it will correct several common misperceptions about vaccines in order to help you formulate a fair and balanced understanding that is supported by accepted vaccine theory and new scientific findings.

Do unvaccinated children pose a higher threat to the public than the vaccinated?

It is often stated that those who choose not to vaccinate their children for reasons of conscience endanger the rest of the public, and this is the rationale behind most of the legislation to end vaccine exemptions currently being considered by federal and state legislators country-wide. You should be aware that the nature of protection afforded by many modern vaccines – and that includes most of the vaccines recommended by the CDC for children – is not consistent with such a statement. I have outlined below the recommended vaccines that cannot prevent transmission of disease either because they are not designed to prevent the transmission of infection (rather, they are intended to prevent disease symptoms), or because they are for non-communicable diseases. People who have not received the vaccines mentioned below pose no higher threat to the general public than those who have, implying that discrimination against non-immunized children in a public school setting may not be warranted.

How often do serious vaccine adverse events happen?

It is often stated that vaccination rarely leads to serious adverse
events. Unfortunately, this statement is not supported by science. A
recent study done in Ontario, Canada, established that vaccination
actually leads to an emergency room visit for 1 in 168 children
following their 12-month vaccination appointment and for 1 in 730
children following their 18-month vaccination appointment (see appendix
for a scientific study, Item #5).

When the risk of an adverse event requiring an ER visit after
well-baby vaccinations is demonstrably so high, vaccination must remain a
choice for parents, who may understandably be unwilling to assume this
immediate risk in order to protect their children from diseases that are
generally considered mild or that their children may never be exposed
to.

In summary: 1) due to the properties of modern vaccines,
non-vaccinated individuals pose no greater risk of transmission of
polio, diphtheria, pertussis, and numerous non-type b H. influenzae
strains than vaccinated individuals do, non-vaccinated individuals pose
virtually no danger of transmission of hepatitis B in a school setting,
and tetanus is not transmissible at all; 2) there is a significantly
elevated risk of emergency room visits after childhood vaccination
appointments attesting that vaccination is not risk-free; 3) outbreaks
of measles cannot be entirely prevented even if we had nearly perfect
vaccination compliance; and 4) an effective method of preventing measles
and other viral diseases in vaccine-ineligible infants and the
immunocompromised, immunoglobulin, is available for those who may be
exposed to these diseases.

Taken together, these four facts make it clear that discrimination in
a public school setting against children who are not vaccinated for
reasons of conscience is completely unwarranted as the vaccine status of
conscientious objectors poses no undue public health risk. 

Unlike most vaccine advocates, who invariably point to irrelevant historical statistics that a) preceded the introduction of vaccines and b) involve vaccines that are very different than the vaccines now administered today, most vaccine skeptics pay close attention to the actual vaccines and vaccine schedules that are presently relevant today. If you’re not reasonably up to date on either when the various vaccines were first introduced or the historical and current death rates, I would advise that you get yourself up to speed before leaping in and saying something both stupid and easily disproved.

And it is important to be up to speed before trying to discuss the subject, because as Dr. Obukhanych observes, the vaccines that are being given today are not the same vaccines that helped wipe out the last vestiges of the various communicable diseases that had already declined dramatically as a result of improved sewage and health care systems.

Furthermore, there is very good reason to doubt the linear efficacy of vaccines that is commonly assumed due to the presence of the 5 percent of the population who are low-vaccine responders. If one factors in the additional percent of the population that is vaccine-sensitive, which is presently unknown but is unlikely to be any smaller than the low-vaccine responder population, somewhere between 5 and 15 percent of the population are simply never going to fit the “one size fits all approach”, which means that any law that would impose such a draconian vaccine regime on the general population is unconscionable, guaranteed to cause more harm than it prevents, and certain to fail in its stated objectives.

But even if one sets aside the science and the history of vaccines, one doesn’t need to be against vaccines or even to question the idea of their unmitigated beneficence in order to strongly oppose the idea of the government universally and forcibly dictating the injection of substances for which there is no legal liability by people for whom there is no legal accountability, without consent or even parental consent, into every single infant in the nation.

And the fact is that vaccines are not an unmitigated good. Like most things, they come with costs and benefits. It is foolish, even criminal, to attempt to set public policy without taking the downside aspects into account as well as the upside ones.

Furthermore, the scare tactics of vaccine advocates are based on absolute and utter absurdities that require complete ignorance of the historical facts to take seriously. Even in a completely
unvaccinated scenario with 90 percent infection rates that assumes
absolutely no improvement in health care in 55 years, we’re talking
about 450 deaths per year.  Realistically, we’re probably talking around
200, given the advancements in medical technology. THAT is what all the
pro-vaccine scaremongers are going on about. Americans would do far better
to ban bicycles, as they would save three times more lives per year.

383,542: Automobile deaths in last 10 years
6,770: Bicycle deaths in last 10 years
0: Measles deaths in last 10 years

As it happens, since 2003, 108 more Americans have died from reactions to the measles vaccine than have died from measles. Vaccine apologists like to claim that anti-vaxxers “have blood on their hands” due to hypothetical deaths that could theoretically occur as a result of imagined transmissions of communicable diseases that haven’t actually taken place, but the fact is that they have real blood from actual deaths on their own.


Vaccines are “safe” and “effective”

Because they are totally “tested”. By scientists doing science:

Merck, the pharmaceutical giant, is facing a slew of controversies over its Measles-Mumps-Rubella (MMR) vaccine following numerous allegations of wrongdoing from different parties in the medical field, including two former Merck scientists-turned-whistleblowers. A third whistleblower, this one a scientist at the Centers for Disease Control, also promises to bring Merck grief following his confession of misconduct involving the same MMR vaccine.

The controversies will find Merck defending itself and its vaccine in at least two federal court cases after a U.S. District judge earlier this month threw out Merck’s attempts at dismissal. Merck now faces federal charges of fraud from the whistleblowers, a vaccine competitor and doctors in New Jersey and New York. Merck could also need to defend itself in Congress: The staff of representative Bill Posey (R-Fla) — a longstanding critic of the CDC interested in an alleged link between vaccines and autism — is now reviewing some 1,000 documents that the CDC whistleblower turned over to them.

The first court case, United States v. Merck & Co., stems from claims by two former Merck scientists that Merck “fraudulently misled the government and omitted, concealed, and adulterated material information regarding the efficacy of its mumps vaccine in violation of the FCA [False Claims Act].”

According to the whistleblowers’ court documents, Merck’s misconduct was far-ranging: It “failed to disclose that its mumps vaccine was not as effective as Merck represented, (ii) used improper testing techniques, (iii) manipulated testing methodology, (iv) abandoned undesirable test results, (v) falsified test data, (vi) failed to adequately investigate and report the diminished efficacy of its mumps vaccine, (vii) falsely verified that each manufacturing lot of mumps vaccine would be as effective as identified in the labeling, (viii) falsely certified the accuracy of applications filed with the FDA, (ix) falsely certified compliance with the terms of the CDC purchase contract, (x) engaged in the fraud and concealment describe herein for the purpose of illegally monopolizing the U.S. market for mumps vaccine, (xi) mislabeled, misbranded, and falsely certified its mumps vaccine, and (xii) engaged in the other acts described herein to conceal the diminished efficacy of the vaccine the government was purchasing.”

These fraudulent activities, say the whistleblowers, were designed to produce test results that would meet the FDA’s requirement that the mumps vaccine was 95 per cent effective. To the whistleblowers’ delight, the judge dismissed Merck’s objections to the case proceeding, finding the whistleblowers had plausible grounds on all of the claims lodged against Merck.

Vaccine advocates, are you starting to find even a glimmering of understanding why some intelligent and well-informed people just might harbor the occasional doubt about the safety and efficacity of vaccines? If not yet, what more will it take? And do you not understand that once this level of fraud is established, it casts at least a modicum of doubt on EVERY SINGLE CLAIM that has been made about vaccine safety in the past?

Perhaps you’ll even be able to understand why doctors have been hesitant to come forward with their doubts about vaccines if you consider the sort of response they can be expected to encounter from the vaccine manufacturers, who are legally protected against being held liable for the deficiencies of their products:

Merck made a “hit list” of doctors who criticized Vioxx, according to testimony in a Vioxx class action case in Australia. The list, emailed between Merck employees, contained doctors’ names with the labels “neutralise,” “neutralised” or “discredit” next to them. 

Do you find that confidence-inspiring?


More measles facts

The US goverment reports more killed by measles vaccinations than by measles in the USA:

While those opposing mandatory vaccination for measles are widely portrayed as ignorant and even dangerous by some officials, pundits and even news media accounts, Centers for Disease Control records reveal a startling truth – while no one has died of measles in the U.S. in the last 12 years, 108 have died as a result of the adverse effects of the vaccine in that same time period.

The death statistics are recorded by Vaccine Adverse Event Reporting System, or VAERS, which captures only a small percentage of the actual number of deaths and other adverse reactions to the vaccine. In addition, 96 of the 108 deaths in that 12-year time period were a result of the MMR vaccine, now the preferred shot for measles immunization.

Now, it’s important not to exaggerate the relative risks involved. Nine deaths per year is still considerably less than the 248 per year I estimate would result from a completely unvaccinated situation. However, given the fact that some countries, such as the UK, have historically seen LOWER rates of measles incidence at moderate levels of vaccine coverage, it is entirely possible that the optimal risk-minimization level of vaccination for measles is considerably below 100 percent.

This may sound counter-intuitive, but a vaccination regime that prioritized testing for vaccine susceptibility and excluded those children deemed likely to experience an adverse reaction would almost certainly meet considerably less virulent opposition than the present one, let alone the more oppressive regime envisioned by some of the more rabid pro-vaxxers. Providing an alternative delayed schedule and stretching it out would almost surely help in this regard as well. The fact is that if you’re genuinely concerned about the falling vaccine uptake, the very last thing you should support is doubling-down on the public pressure and propaganda approach. It not only isn’t working, it is observably backfiring.

No amount of propaganda is going to convince anyone who has seen, with their own eyes, an adverse reaction, or had one described to them. And adverse reactions most certainly do happen. That’s a fact, and the sooner the pro-vaccine community accepts it and stops trying to hide it, the sooner a more effective solution can be found.

Nothing creates more fear, uncertainty, and doubt than shaded truths and a blanket refusal to answer obvious questions. Rhetoric is no answer for serious doubts, be they reasonable or unreasonable. And as for increasing the pressure via legal means, it shouldn’t take a vast amount of foresight to anticipate what sort of adverse reactions are going to occur if doctors begin forcibly administering vaccines to children without parental consent and a child subsequently experiences a fatal adverse reaction.

One unanticipated outcome of forced vaccinations could well be the complete refusal of medical professionals to administer them.